Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

An immunogenetic basis for lung cancer risk.

Science (New York, N.Y.) - 23 Feb 2024

Krishna Chirag, Tervi Anniina, Saffern Miriam, Wilson Eric A, Yoo Seong-Keun, Mars Nina, Roudko Vladimir, Cho Byuri Angela, Jones Samuel Edward, Vaninov Natalie, Selvan Myvizhi Esai, Gümüş Zeynep H, Lenz Tobias L, Merad Miriam, Boffetta Paolo, Martínez-Jiménez Francisco, Ollila Hanna M, Samstein Robert M, Chowell Diego

Abstract excerpt

Cancer risk is influenced by inherited mutations, DNA replication errors, and environmental factors. However, the influence of genetic variation in immunosurveillance on cancer risk is not well understood. Leveraging population-level data from the UK Biobank and FinnGen, we show that heterozygosity at the human leukocyte antigen (HLA)-II loci is associated with reduced lung cancer risk in smokers. Fine-mapping...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged, 80 and over
Share to Chromosome Mapping

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Histocompatibility Antigens Class II

Share to Immunologic Surveillance

Share to Loss of Heterozygosity

Share to Lung Neoplasms

Share to Macrophages, Alveolar

Share to Smoking

Source

Open in PubMed Open full text

Identifiers

PMID: 38386728
DOI: 10.1126/science.adi3808
PMCID: PMC11998992

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

An immunogenetic basis for lung cancer risk.PMID 38386728Read ↗

Germline HLA heterozygosity is associated with decreased lung cancer risk.Semantic proximity Read ↗

Allele-Specific HLA Loss and Immune Escape in Lung Cancer Evolution.Semantic proximity Read ↗

MHC Hammer reveals genetic and non-genetic HLA disruption in cancer evolution.Semantic proximity Read ↗

Somatic HLA Class I Loss Is a Widespread Mechanism of Immune Evasion Which Refines the Use of Tumor Mutational Burden as a Biomarker of Checkpoint Inhibitor Response.Semantic proximity Read ↗

Fine-mapping the MHC region in Asian populations identified novel variants modifying susceptibility to lung cancer.Semantic proximity Read ↗

Multidimensional bioinformatics perspective on smoking-linked driver genes and immune regulatory mechanisms in non-small cell lung cancerSemantic proximity Read ↗

Immune-mediated genetic pathways resulting in pulmonary function impairment increase lung cancer susceptibility.Semantic proximity Read ↗

Spatial Analysis and Clinical Significance of HLA Class-I and Class-II Subunit Expression in Non-Small Cell Lung Cancer.Semantic proximity Read ↗

Genomic Profiling of Patient-Derived Xenografts for Lung Cancer Identifies <i>B2M</i> Inactivation Impairing ImmunorecognitionSemantic proximity Read ↗

Whole exome sequencing and machine learning germline analysis of individuals presenting with extreme phenotypes of high and low risk of developing tobacco-associated lung adenocarcinoma.Semantic proximity Read ↗

Genomic Profiling of Patient-Derived Xenografts for Lung Cancer Identifies B2M Inactivation Impairing Immunorecognition.Semantic proximity Read ↗

Smoking-dependent expression alterations in nasal epithelium reveal immune impairment linked to germline variation and lung cancer riskSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.