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Article

Using Separation-of-Function Mutagenesis To Define the Full Spectrum of Activities Performed by the Est1 Telomerase Subunit in Vivo.

Genetics - 1 Jan 2018

Lubin Johnathan W, Tucey Timothy M, Lundblad Victoria

Abstract excerpt

A leading objective in biology is to identify the complete set of activities that each gene performs in vivo In this study, we have asked whether a genetic approach can provide an efficient means of achieving this goal, through the identification and analysis of a comprehensive set of separation-of-function (sof-) mutations in a gene. Toward this goal, we have subjected the Saccharomyces cerevisiae EST1 gene,...

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Identifiers

PMID: 29187507
DOI: 10.1534/genetics.117.300145
PMCID: PMC5753878

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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