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Article

Essential functions of amino-terminal domains in the yeast telomerase catalytic subunit revealed by selection for viable mutants.

Genes & development - 1 Nov 1999

Friedman K L, Cech T R

Abstract excerpt

Telomerase is a ribonucleoprotein complex that adds telomeric DNA repeats to the ends of most eukaryotic chromosomes. The reverse transcriptase subunit of telomerase (TERT) differs from retroviral reverse transcriptases in having a long basic amino-terminal extension. We made a large library containing random mutations in the amino terminus of the EST2 gene, which encodes the Saccharomyces cerevisiae TERT, and...

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Identifiers

PMID: 10557213
DOI: 10.1101/gad.13.21.2863
PMCID: PMC317136

Genes

TERT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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