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Article

The interaction between the yeast telomerase RNA and the Est1 protein requires three structural elements.

RNA (New York, N.Y.) - 1 Sept 2012

Lubin Johnathan W, Tucey Timothy M, Lundblad Victoria

Abstract excerpt

In the budding yeast Saccharomyces cerevisiae, the telomerase enzyme is composed of a 1.3-kb TLC1 RNA that forms a complex with Est2 (the catalytic subunit) and two regulatory proteins, Est1 and Est3. Previous work has identified a conserved 5-nt bulge, present in a long helical arm of TLC1, which mediates binding of Est1 to TLC1. However, increased expression of Est1 can bypass the consequences of removal of...

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Identifiers

PMID: 22847816
DOI: 10.1261/rna.034447.112
PMCID: PMC3425775

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Source receipt: pubmed, retrieved 7 Sept 2026.

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The interaction between the yeast telomerase RNA and the Est1 protein requires three structural elements.PMID 22847816Read ↗

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