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Article

The mechanisms of K. lactis Cdc13 in telomere DNA-binding and telomerase regulation.

DNA repair - 1 Jan 2018

Hsu Min, Lue Neal F

Abstract excerpt

Eukaryotic chromosome ends, or telomeres, are essential for genome stability and are protected by an intricate nucleoprotein assembly. Cdc13, the major single-strand telomere-binding protein in budding yeasts, mediates critical functions in both telomere protection and telomere elongation by telomerase. In particular, the interaction between S. cerevisiae Cdc13 and telomerase subunit Est1 has long served as a...

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Identifiers

PMID: 29197718
DOI: 10.1016/j.dnarep.2017.11.007
PMCID: PMC5766012

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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The mechanisms of K. lactis Cdc13 in telomere DNA-binding and telomerase regulation.PMID 29197718Read ↗

The telomeric Cdc13 protein interacts directly with the telomerase subunit Est1 to bring it to telomeric DNA ends in vitro.Semantic proximity Read ↗

Est1 and Cdc13 as comediators of telomerase access.Semantic proximity Read ↗

The Saccharomyces telomere-binding protein Cdc13p interacts with both the catalytic subunit of DNA polymerase alpha and the telomerase-associated est1 protein.Semantic proximity Read ↗

A yeast telomerase complex containing the Est1 recruitment protein is assembled early in the cell cycle.Semantic proximity Read ↗

Cdc13 cooperates with the yeast Ku proteins and Stn1 to regulate telomerase recruitment.Semantic proximity Read ↗

Telomere-binding and Stn1p-interacting activities are required for the essential function of Saccharomyces cerevisiae Cdc13p.Semantic proximity Read ↗

A second essential function of the Est1-binding arm of yeast telomerase RNA.Semantic proximity Read ↗

Linear chromosome maintenance in the absence of essential telomere-capping proteins.Semantic proximity Read ↗

A genomewide suppressor and enhancer analysis of cdc13-1 reveals varied cellular processes influencing telomere capping in Saccharomyces cerevisiae.Semantic proximity Read ↗

The Est1 subunit of yeast telomerase binds the Tlc1 telomerase RNA.Semantic proximity Read ↗

Cdc13p: a single-strand telomeric DNA-binding protein with a dual role in yeast telomere maintenance.Semantic proximity Read ↗

Stimulation of yeast telomerase activity by the ever shorter telomere 3 (Est3) subunit is dependent on direct interaction with the catalytic protein Est2.Semantic proximity Read ↗

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