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Article

Improving Polymerase Activity with Unnatural Substrates by Sampling Mutations in Homologous Protein Architectures.

ACS chemical biology - 20 May 2016

Dunn Matthew R, Otto Carine, Fenton Kathryn E, Chaput John C

Abstract excerpt

The ability to synthesize and propagate genetic information encoded in the framework of xeno-nucleic acid (XNA) polymers would inform a wide range of topics from the origins of life to synthetic biology. While directed evolution has produced examples of engineered polymerases that can accept XNA substrates, these enzymes function with reduced activity relative to their natural counterparts. Here, we describe a...

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Identifiers

PMID: 26860781
DOI: 10.1021/acschembio.5b00949

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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