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Directed polymerase evolution.

FEBS letters - 21 Jan 2014

Chen Tingjian, Romesberg Floyd E

Abstract excerpt

Polymerases evolved in nature to synthesize DNA and RNA, and they underlie the storage and flow of genetic information in all cells. The availability of these enzymes for use at the bench has driven a revolution in biotechnology and medicinal research; however, polymerases did not evolve to function efficiently under the conditions required for some applications and their high substrate fidelity precludes their...

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Identifiers

PMID: 24211837
DOI: 10.1016/j.febslet.2013.10.040
PMCID: PMC3982152

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