Genomic structures of the human and murine corin genes and functional GATA elements in their promoters.

doi:10.1074/jbc.M205686200

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Article

Genomic structures of the human and murine corin genes and functional GATA elements in their promoters.

The Journal of biological chemistry - 11 Oct 2002

Pan Junliang, Hinzmann Bernd, Yan Wei, Wu Faye, Morser John, Wu Qingyu

Abstract excerpt

Corin is a multiple-domain type II transmembrane serine protease highly expressed in the heart. It converts pro-atrial natriuretic peptide to atrial natriuretic peptide, a cardiac hormone that regulates blood volume and pressure. Here we describe the genomic structures of the human and murine corin genes and functional analysis of their promoters. Both corin genes contain 22 exons and span >200 kb. Their...

Topics

Animals
Base Sequence
Binding Sites
DNA-Binding Proteins
Exons
GATA4 Transcription Factor
Gene Expression Regulation
Genes
Genes, Reporter
HeLa Cells
Heart
Humans
Membrane Proteins
Mice
Molecular Sequence Data

Source

Open in PubMed

Identifiers

PMID: 12154094
DOI: 10.1074/jbc.M205686200

Genes

TBX5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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Muscle Proteins

Mutation

Myocytes, Cardiac