Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Impact of multi-gene mutational profiling on clinical trial outcomes in metastatic breast cancer.

Breast cancer research and treatment - 1 Feb 2018

Pezo Rossanna C, Chen Tom W, Berman Hal K, Mulligan Anna M, Razak Albiruni A, Siu Lillian L, Cescon David W, Amir Eitan, Elser Christine, Warr David G, Sridhar Srikala S, Yu Celeste, Wang Lisa, Stockley Tracy L, Kamel-Reid Suzanne, Bedard Philippe L

Abstract excerpt

PURPOSE: Next-generation sequencing (NGS) has identified recurrent genomic alterations in metastatic breast cancer (MBC); however, the clinical utility of incorporating routine sequencing to guide treatment decisions in this setting is unclear. We examine the frequency of genomic alterations in MBC patients from academic and community hospitals and correlate with clinical outcomes. METHODS: MBC patients with good...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antineoplastic Agents
Share to Breast

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Clinical Trials as Topic

Share to Genotyping Techniques

Share to High-Throughput Nucleotide Sequencing

Share to Mastectomy

Share to PTEN Phosphohydrolase

Share to Survival Analysis

Source

Open in PubMed Open full text

Identifiers

PMID: 29177603
DOI: 10.1007/s10549-017-4580-2
PMCID: PMC5847065

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Impact of multi-gene mutational profiling on clinical trial outcomes in metastatic breast cancer.PMID 29177603Read ↗

Clinical outcomes based on multigene profiling in metastatic breast cancer patients.Semantic proximity Read ↗

Targeted next-generation sequencing detects a high frequency of potentially actionable mutations in metastatic breast cancers.Semantic proximity Read ↗

Impact of tissue-based genomic profiling on clinical decision making in the management of patients with metastatic breast cancer at academic centers.Semantic proximity Read ↗

Multigene clinical mutational profiling of breast carcinoma using next-generation sequencing.Semantic proximity Read ↗

Clinical implications of genomic profiles in metastatic breast cancer with a focus on TP53 and PIK3CA, the most frequently mutated genes.Semantic proximity Read ↗

Genomic, Transcriptomic, and Proteomic Profiling of Metastatic Breast Cancer.Semantic proximity Read ↗

Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients.Semantic proximity Read ↗

Survival Outcomes by TP53 Mutation Status in Metastatic Breast CancerSemantic proximity Read ↗

Genomic profiling of advanced-stage, metaplastic breast carcinoma by next-generation sequencing reveals frequent, targetable genomic abnormalities and potential new treatment options.Semantic proximity Read ↗

Molecular profiling of advanced solid tumors and patient outcomes with genotype-matched clinical trials: the Princess Margaret IMPACT/COMPACT trial.Semantic proximity Read ↗

Tumor Tissue- versus Plasma-based Genotyping for Selection of Matched Therapy and Impact on Clinical Outcomes in Patients with Metastatic Breast Cancer.Semantic proximity Read ↗

DNA damage response as a prognostic indicator in metastatic breast cancer via mutational analysisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.