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Article

Targeted next-generation sequencing detects a high frequency of potentially actionable mutations in metastatic breast cancers.

Experimental and molecular pathology - 1 Jun 2016

Muller Kristen E, Marotti Jonathan D, de Abreu Francine B, Peterson Jason D, Miller Todd W, Chamberlin Mary D, Tsongalis Gregory J, Tafe Laura J

Abstract excerpt

BACKGROUND: Metastatic breast cancer is a genetically heterogeneous disease and effective therapies for advanced stage disease are limited. METHODS: In this study, distant metastases of 22 formalin-fixed, paraffin-embedded (FFPE) breast cancer samples were sequenced using the Ion Torrent PGM and the 50 gene AmpliSeq Cancer Hotspot Panel v2 from 10ng of extracted DNA using 318 chips. Data analysis was performed...

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Source

Identifiers

PMID: 27095739
DOI: 10.1016/j.yexmp.2016.04.002

Genes

AKT1
APC
ERBB2
FGFR3
KRAS
MET

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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