Article
Clinical outcomes based on multigene profiling in metastatic breast cancer patients.
Oncotarget - 22 Nov 2016
Basho Reva K, de Melo Gagliato Debora, Ueno Naoto T, Wathoo Chetna, Chen Huiqin, Shariati Maryam, Wei Caimiao, Alvarez Ricardo H, Moulder Stacy L, Sahin Aysegul A, Roy-Chowdhuri Sinchita, Chavez-MacGregor Mariana, Litton Jennifer K, Valero Vincent, Luthra Raja, Zeng Jia, Shaw Kenna R, Mendelsohn John, Mills Gordon B, Tripathy Debu, Meric-Bernstam Funda
Abstract excerpt
BACKGROUND: Identifying the clinical impact of recurrent mutations can help define their role in cancer. Here, we identify frequent hotspot mutations in metastatic breast cancer (MBC) patients and associate them with clinical outcomes. PATIENTS AND METHODS: Hotspot mutation testing was conducted in 500 MBC patients using an 11 gene (N = 126) and/or 46 or 50 gene (N = 391) panel. Patients were stratified by...
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