Multigene clinical mutational profiling of breast carcinoma using next-generation sequencing.

doi:10.1309/AJCPWDEQYCYC92JQ

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Article

Multigene clinical mutational profiling of breast carcinoma using next-generation sequencing.

American journal of clinical pathology - 1 Nov 2015

Roy-Chowdhuri Sinchita, de Melo Gagliato Debora, Routbort Mark J, Patel Keyur P, Singh Rajesh R, Broaddus Russell, Lazar Alexander J, Sahin Aysegul, Alvarez Ricardo H, Moulder Stacy, Wheler Jennifer J, Janku Filip, Gonzalez-Angulo Ana M, Chavez-MacGregor Mariana, Valero Vicente, Ueno Naoto T, Mills Gordon, Mendelsohn John, Yao Hui, Aldape Kenneth, Luthra Rajyalakshmi, Meric-Bernstam Funda

Abstract excerpt

OBJECTIVES: The advent of next-generation sequencing (NGS) platforms in the realm of clinical molecular diagnostics provides multigene mutational profiling through massively parallel sequencing. METHODS: We analyzed 415 breast carcinoma samples from 354 patients using NGS in known hotspots of 46 commonly known cancer-causing genes. RESULTS: A total of 281 somatic nonsynonymous mutations were detected in 62.1% of...

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PMID: 26486734
DOI: 10.1309/AJCPWDEQYCYC92JQ

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