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Article

Clinical implications of genomic profiles in metastatic breast cancer with a focus on TP53 and PIK3CA, the most frequently mutated genes.

Oncotarget - 25 Apr 2017

Kim Ji-Yeon, Lee Eunjin, Park Kyunghee, Park Woong-Yang, Jung Hae Hyun, Ahn Jin Seok, Im Young-Hyuck, Park Yeon Hee

Abstract excerpt

Breast cancer (BC) has been genetically profiled through large-scale genome analyses. However, the role and clinical implications of genetic alterations in metastatic BC (MBC) have not been evaluated. Therefore, we conducted whole-exome sequencing (WES) and RNA-Seq of 37 MBC samples and targeted deep sequencing of another 29 MBCs. We evaluated somatic mutations from WES and targeted sequencing and assessed gene...

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Identifiers

PMID: 28427202
DOI: 10.18632/oncotarget.15881
PMCID: PMC5438625

Genes

CALM1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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