Article
Molecular profiling of advanced solid tumors and patient outcomes with genotype-matched clinical trials: the Princess Margaret IMPACT/COMPACT trial.
Genome medicine - 25 Oct 2016
Stockley Tracy L, Oza Amit M, Berman Hal K, Leighl Natasha B, Knox Jennifer J, Shepherd Frances A, Chen Eric X, Krzyzanowska Monika K, Dhani Neesha, Joshua Anthony M, Tsao Ming-Sound, Serra Stefano, Clarke Blaise, Roehrl Michael H, Zhang Tong, Sukhai Mahadeo A, Califaretti Nadia, Trinkaus Mateya, Shaw Patricia, van der Kwast Theodorus, Wang Lisa, Virtanen Carl, Kim Raymond H, Razak Albiruni R A, Hansen Aaron R, Yu Celeste, Pugh Trevor J, Kamel-Reid Suzanne, Siu Lillian L, Bedard Philippe L
Abstract excerpt
BACKGROUND: The clinical utility of molecular profiling of tumor tissue to guide treatment of patients with advanced solid tumors is unknown. Our objectives were to evaluate the frequency of genomic alterations, clinical "actionability" of somatic variants, enrollment in mutation-targeted or other clinical trials, and outcome of molecular profiling for advanced solid tumor patients at the Princess Margaret Cancer...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.