Article
Quorum Sensing Down-Regulation Counteracts the Negative Impact of Pseudomonas aeruginosa on CFTR Channel Expression, Function and Rescue in Human Airway Epithelial Cells.
Frontiers in cellular and infection microbiology - 1 Jan 2017
Maillé Émilie, Ruffin Manon, Adam Damien, Messaoud Hatem, Lafayette Shantelle L, McKay Geoffrey, Nguyen Dao, Brochiero Emmanuelle
Abstract excerpt
The function of cystic fibrosis transmembrane conductance regulator (CFTR) channels is crucial in human airways. However unfortunately, chronic Pseudomonas aeruginosa infection has been shown to impair CFTR proteins in non-CF airway epithelial cells (AEC) and to alter the efficiency of new treatments with CFTR modulators designed to correct the basic CFTR default in AEC from cystic fibrosis (CF) patients carrying...
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