Article
Variables that influence BRAF mutation probability: A next-generation sequencing, non-interventional investigation of BRAFV600 mutation status in melanoma.
PloS one - 1 Jan 2017
Gaiser Maria Rita, Skorokhod Alexander, Gransheier Diana, Weide Benjamin, Koch Winfried, Schif Birgit, Enk Alexander, Garbe Claus, Bauer Jürgen
Abstract excerpt
BACKGROUND: The incidence of melanoma, particularly in older patients, has steadily increased over the past few decades. Activating mutations of BRAF, the majority occurring in BRAFV600, are frequently detected in melanoma; however, the prognostic significance remains unclear. This study aimed to define the probability and distribution of BRAFV600 mutations, and the clinico-pathological factors that may affect...
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