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The Impact of BRAF Mutational Status on Survival in Melanoma Patients: Single Centre Experience.

Acta dermatovenerologica Croatica : ADC - 1 Dec 2025

Kovač Leo, Žauhar Gordana, Vučinić Damir, Hadžisejdić Ita, Fučkar Čupić Dora, Jonjić Nives

Abstract excerpt

Melanoma accounts for less than 2% of all cancers worldwide but is responsible for 80% of skin cancer-related deaths. Among the various genetic alterations in melanoma, BRAF and NRAS mutations are the most common. While multiple studies have confirmed the involvement of BRAF in melanoma, its role as a prognostic marker remains disputed. However, the BRAF V600E mutation is clinically significant, as its presence...

Topics

Humans
Melanoma
Proto-Oncogene Proteins B-raf
Skin Neoplasms
Retrospective Studies
Mutation
Female
Male
Middle Aged
Aged
Prognosis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Adult

Aged, 80 and over

Source

Identifiers

PMID: 42370653

Genes

BRAF
NRAS

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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