Dissecting the Spectrum of Rare BRAF Mutations in Melanoma: A Nation-Wide Study by the Italian Melanoma Intergroup (IMI).

doi:10.1111/pcmr.70087

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Dissecting the Spectrum of Rare BRAF Mutations in Melanoma: A Nation-Wide Study by the Italian Melanoma Intergroup (IMI).

Pigment cell & melanoma research - 1 May 2026

Dalmasso Bruna, Scaini Maria Chiara, Cendron Laura, Rodolfo Monica, Mattavelli Ilaria, Tamborini Elena, Collina Francesca, Ferrara Gerardo, Madonna Gabriele, Cota Carlo, Melucci Elisa, Tommasi Stefania, Ubaldi Martina, Depenni Roberta, Carugno Andrea, Marconcini Riccardo, Orgiano Laura, Lombardo Maurizio, Sola Simona, Pellegrini Cristina, Castiglione Francesca, Gasparotto Matteo, Jorkesh Alireza, Pellegrini Stefania, Raposio Edoardo, Boutros Andrea, Tanda Enrica Teresa, Guida Michele, Quaglino Pietro, Palmieri Giuseppe, Massi Daniela, Ascierto Paolo Antonio, Spagnolo Francesco, Mandalà Mario, Menin Chiara, Ghiorzo Paola, Pastorino Lorenza

Abstract excerpt

Non-V600E/K BRAF mutations have been reported in melanoma, but data on their clinical relevance are conflicting. This study investigated the distribution, prognostic role, and functional impact of rare BRAF mutations in melanoma. We retrospectively assessed frequency, response to therapy and outcome of rare BRAF mutations compared to V600E/K in cases from 19 Italian Melanoma group (IMI) centers. 258/14,081...

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PMID: 42003243
DOI: 10.1111/pcmr.70087
PMCID: PMC13092998

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