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Age-related next-generation sequencing mutational analysis in 1196 melanomas.

Journal of surgical oncology - 1 Jun 2023

Santamaria-Barria Juan A, Matsuba Chikako, Khader Adam, Scholar Anthony J, Garland-Kledzik Mary, Fischer Trevan D, Essner Richard, Salomon Matthew P, Mammen Joshua M V, Goldfarb Melanie

Abstract excerpt

BACKGROUND AND OBJECTIVES: Melanoma mutational burden is high and approximately 50% have oncogenic mutations in BRAF. We sought to evaluate age-related mutational differences in melanoma. METHODS: We analyzed melanoma samples in the Genomics Evidence Neoplasia Information Exchange database. Targetable mutations were identified using the Precision Oncology Knowledge Base (OncoKB). RESULTS: We found 1194 patients...

Topics

Humans
Adult
Proto-Oncogene Proteins B-raf
Precision Medicine
Melanoma
Mutation
High-Throughput Nucleotide Sequencing
DNA Mutational Analysis
Skin Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 36938777
DOI: 10.1002/jso.27239

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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