Article
Clinical mutational profiling and categorization of BRAF mutations in melanomas using next generation sequencing.
BMC cancer - 5 Jul 2019
Lokhandwala Parvez M, Tseng Li-Hui, Rodriguez Erika, Zheng Gang, Pallavajjalla Aparna, Gocke Christopher D, Eshleman James R, Lin Ming-Tseh
Abstract excerpt
BACKGROUND: Analysis of melanomas for actionable mutations has become the standard of care. Recently, a classification scheme has been proposed that categorizes BRAF mutations based on their mechanisms for activation of the MAPK pathway. METHODS: In this analysis BRAF, KIT, NRAS, and PIK3CA mutations were examined by next generation sequencing (NGS) in 446 melanomas in a clinical diagnostic setting. KRAS and HRAS...
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