Beyond BRAF(V600): clinical mutation panel testing by next-generation sequencing in advanced melanoma.

doi:10.1038/jid.2014.366

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Article

Beyond BRAF(V600): clinical mutation panel testing by next-generation sequencing in advanced melanoma.

The Journal of investigative dermatology - 1 Feb 2015

Siroy Alan E, Boland Genevieve M, Milton Denái R, Roszik Jason, Frankian Silva, Malke Jared, Haydu Lauren, Prieto Victor G, Tetzlaff Michael, Ivan Doina, Wang Wei-Lien, Torres-Cabala Carlos, Curry Jonathan, Roy-Chowdhuri Sinchita, Broaddus Russell, Rashid Asif, Stewart John, Gershenwald Jeffrey E, Amaria Rodabe N, Patel Sapna P, Papadopoulos Nicholas E, Bedikian Agop, Hwu Wen-Jen, Hwu Patrick, Diab Adi, Woodman Scott E, Aldape Kenneth D, Luthra Rajyalakshmi, Patel Keyur P, Shaw Kenna R, Mills Gordon B, Mendelsohn John, Meric-Bernstam Funda, Kim Kevin B, Routbort Mark J, Lazar Alexander J, Davies Michael A

Abstract excerpt

The management of melanoma has evolved owing to improved understanding of its molecular drivers. To augment the current understanding of the prevalence, patterns, and associations of mutations in this disease, the results of clinical testing of 699 advanced melanoma patients using a pan-cancer next-generation sequencing (NGS) panel of hotspot regions in 46 genes were reviewed. Mutations were identified in 43 of...

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Identifiers

PMID: 25148578
DOI: 10.1038/jid.2014.366
PMCID: PMC4289407

Genes

NRAS
KIT
BRAF

Provenance

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Source receipt: pubmed, retrieved 7 Sept 2026.

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