Article

RNA and DNA G-quadruplexes bind to human Dicer and inhibit its activity

2020-05-07

Abstract excerpt

Guanine (G)-rich single-stranded nucleic acids can adopt G-quadruplex structures. Accumulating evidence indicates that G-quadruplexes serve important regulatory roles in fundamental biological processes such as DNA replication, transcription, and translation, while aberrant G-quadruplex formation is linked to genome instability and cancer. Understanding the biological functions played by G-quadruplexes requires de...

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Literature Corpus work: 1b4d96fc-1195-5c3d-a8de-90cefba9c6a6
DOI: 10.1101/2020.05.05.078592

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