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Article

Posttranscriptional Regulation of LOXL1 Expression Via Alternative Splicing and Nonsense-Mediated mRNA Decay as an Adaptive Stress Response.

Investigative ophthalmology & visual science - 1 Nov 2017

Berner Daniel, Zenkel Matthias, Pasutto Francesca, Hoja Ursula, Liravi Panah, Gusek-Schneider Gabriele C, Kruse Friedrich E, Schödel Johannes, Reis Andre, Schlötzer-Schrehardt Ursula

Abstract excerpt

Purpose: Alternative mRNA splicing coupled to nonsense-mediated decay (NMD) is a common mRNA surveillance pathway also known to dynamically modulate gene expression in response to cellular stress. Here, we investigated the involvement of this pathway in the regulation of lysyl oxidase-like 1 (LOXL1) expression in response to pseudoexfoliation (PEX)-associated pathophysiologic factors. Methods: Transcript levels...

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Source

Identifiers

PMID: 29164236
DOI: 10.1167/iovs.17-22963

Genes

LOXL1
SMG1
UPF1
UPF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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