Article
Identification and activity of the functional complex between hnRNPL and the pseudoexfoliation syndrome-associated lncRNA, LOXL1-AS1.
Human molecular genetics - 29 Jul 2020
Schmitt Heather M, Johnson William M, Aboobakar Inas F, Strickland Shelby, Gomez-Caraballo María, Parker Megan, Finnegan Laura, Corcoran David L, Skiba Nikolai P, Allingham R Rand, Hauser Michael A, Stamer W Daniel
Abstract excerpt
Individuals with pseudoexfoliation (PEX) syndrome exhibit various connective tissue pathologies associated with dysregulated extracellular matrix homeostasis. PEX glaucoma is a common, aggressive form of open-angle glaucoma resulting from the deposition of fibrillary material in the conventional outflow pathway. However, the molecular mechanisms that drive pathogenesis and genetic risk remain poorly understood....
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