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Article

Expression and Regulation of LOXL1 and Elastin-related Genes in Eyes With Exfoliation Syndrome

1 Jan 2014

Abstract excerpt

Exfoliation syndrome (XFS) is a complex, late-onset disorder of the elastic fiber system and the most common identifiable cause of open-angle glaucoma. Strong genetic risk is conferred by the lysyl oxidase-like 1 (LOXL1) gene, but additional comodulating factors are necessary for the manifestation of the disease. The aim of this study was to establish a comprehensive expression profile of LOXL1 and elastic...

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PMID: 25275906
DOI: 10.1097/ijg.0000000000000120

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