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Article

Molecular pathology of pseudoexfoliation syndrome/glaucoma--new insights from LOXL1 gene associations.

Experimental eye research - 1 Apr 2009

Schlötzer-Schrehardt Ursula

Abstract excerpt

Pseudoexfoliation (PEX) syndrome is a generalized disease of the extracellular matrix and a major cause of severe open-angle glaucoma. Single nucleotide polymorphisms (SNPs) in exon 1 of the lysyl oxidase-like 1 (LOXL1) gene have been recently identified as strong genetic risk factors for both PEX syndrome and PEX glaucoma. LOXL1 is a pivotal cross-linking enzyme in extracellular matrix metabolism and seems to be...

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Share to Amino Acid Oxidoreductases
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Microbial metabolism and enzyme function

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Source

Identifiers

PMID: 18809397
DOI: 10.1016/j.exer.2008.08.012

Genes

LOXL1

Provenance

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