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Article

Lysyl Oxidase Like 1: Biological roles and regulation.

Experimental eye research - 1 Apr 2020

Greene Alison G, Eivers Sarah B, Dervan Edward W J, O'Brien Colm J, Wallace Deborah M

Abstract excerpt

Lysyl Oxidase Like 1 (LOXL1) is a gene that encodes for the LOXL1 enzyme. This enzyme is required for elastin biogenesis and collagen cross-linking, polymerising tropoelastin monomers into elastin polymers. Its main role is in elastin homeostasis and matrix remodelling during injury, fibrosis and cancer development. Because of its vast range of biological functions, abnormalities in LOXL1 underlie many disease...

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Alleles
Extracellular Matrix Proteins
Genetic Predisposition to Disease
Glaucoma
Polymorphism, Single Nucleotide

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein-Lysine 6-Oxidase

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PMID: 32070696
DOI: 10.1016/j.exer.2020.107975

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