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Article

Ancestral LOXL1 variants are associated with pseudoexfoliation in Caucasian Australians but with markedly lower penetrance than in Nordic people.

Human molecular genetics - 1 Mar 2008

Hewitt Alex W, Sharma Shiwani, Burdon Kathryn P, Wang Jie Jin, Baird Paul N, Dimasi David P, Mackey David A, Mitchell Paul, Craig Jamie E

Abstract excerpt

Pseudoexfoliation syndrome is a generalized disorder of the extracellular matrix, characterized by the pathological accumulation of abnormal fibrillar material in the anterior segment of the eye predisposing to glaucomatous optic neuropathy. We investigated the role of lysyl oxidase-like 1(LOXL1) sequence variation in a Caucasian Australian population-based cohort of 2508 individuals, 86 (3.4%) of whom were...

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Source

Identifiers

PMID: 18037624
DOI: 10.1093/hmg/ddm342

Genes

LOXL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Ancestral LOXL1 variants are associated with pseudoexfoliation in Caucasian Australians but with markedly lower penetrance than in Nordic people.PMID 18037624Read ↗

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