[New pathogenetic insights into pseudoexfoliation syndrome/glaucoma. Therapeutically relevant?].

Abstract excerpt

Pseudoexfoliation (PEX) syndrome is a genetically determined, generalized disease of the extracellular matrix leading to the progressive deposition of an abnormal fibrillar material in various intraocular and extraocular tissues including the trabecular meshwork. It thus represents the most common identifiable cause of open-angle glaucoma and a leading cause of blindness worldwide. The PEX-specific fibrotic...

Topics

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• Elastic Tissue
• Exfoliation Syndrome
• Intraocular Pressure
• Matrix Metalloproteinases
• Optic Nerve