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Article

Regulation of lysyl oxidase-like 1 (LOXL1) and elastin-related genes by pathogenic factors associated with pseudoexfoliation syndrome.

Investigative ophthalmology & visual science - 31 Oct 2011

Zenkel Matthias, Krysta Anita, Pasutto Francesca, Juenemann Anselm, Kruse Friedrich E, Schlötzer-Schrehardt Ursula

Abstract excerpt

PURPOSE: Pseudoexfoliation (PEX) syndrome/glaucoma is a complex, late-onset disorder of the elastic fiber system. Strong genetic risk is conferred by the lysyl oxidase-like 1 (LOXL1) gene, but additional comodulating factors are necessary for the manifestation of the disease. The aim of this study was to analyze the effect of various PEX-associated pathogenic factors on the genotype-correlated expression of LOXL1...

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Source

Identifiers

PMID: 21948647
DOI: 10.1167/iovs.11-8361

Genes

LOXL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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