Article
The thymidylate synthase enhancer region (TSER) polymorphism increases the risk of thymic lymphoid hyperplasia in patients with Myasthenia Gravis.
Gene - 5 Feb 2018
Lopomo Angela, Ricciardi Roberta, De Rosa Anna, Guida Melania, Maestri Michelangelo, Lucchi Marco, Melfi Franca, Mussi Alfredo, Migliore Lucia, Coppedè Fabio
Abstract excerpt
BACKGROUND: Myasthenia Gravis (MG) is caused, in approximately 80% of the patients, by autoantibodies against the nicotinic acetylcholine receptor (AChR). The disease is often associated with pathological changes of the thymus: thymic epithelial tumours are present in about 10-20% of the patients, while up to 80% of the patients with early disease onset have thymic hyperplasia. Folate metabolism is required for...
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