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Article

Evidence for association of STAT4 and IL12RB2 variants with Myasthenia gravis susceptibility: What is the effect on gene expression in thymus?

Journal of neuroimmunology - 15 Jun 2018

Zagoriti Zoi, Lagoumintzis George, Perroni Gianluca, Papathanasiou George, Papadakis Andreas, Ambrogi Vincenzo, Mineo Tommaso Claudio, Tzartos John S, Poulas Konstantinos

Abstract excerpt

Myasthenia gravis (MG) is an autoimmune disease mediated by the presence of autoantibodies that bind mainly to the acetylcholine receptor (AChR) in the neuromuscular junction. In our case-control association study, we analyzed common variants located in genes of the IL12/STAT4 and IL10/STAT3 signaling pathways. A total of 175 sporadic MG patients of Greek descent, positively detected with anti-AChR autoantibodies...

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Identifiers

PMID: 29576322
DOI: 10.1016/j.jneuroim.2018.03.008

Genes

STAT4
STAT3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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