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Article

The association between two polymorphisms in the TS gene and risk of cancer: a systematic review and pooled analysis.

International journal of cancer - 1 Nov 2012

Zhou Jue-Yu, Shi Rong, Yu Hai-Lang, Zeng Ye, Zheng Wen-Ling, Ma Wen-Li

Abstract excerpt

Thymidylate synthase (TS) is an important enzyme involved in folate metabolism and catalyzes methylation of deoxyuridine monophosphate to deoxythymidine monophosphate, which is essential for DNA replication. Thymidylate synthase enhancer region (TSER) and TS1494del6, two functionally important and ethnically diverse polymorphisms mapping to its gene region, are the most extensively studied. Considering the...

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PMID: 22307944
DOI: 10.1002/ijc.27465

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