Article
Elucidating genetic backgrounds of myasthenia gravis in Japanese by genome-wide association studies and multi-omics analyses of thymoma.
Nature communications - 12 Mar 2026
Ueda Hiroyuki, Kubota Tomoya, Goto Risa, Suzuki Akari, Ojima Takafumi, Ogawa Kotaro, Sonehara Kyuto, Namba Shinichi, Naito Tatsuhiko, Wang Qingbo, Konno Shingo, Samukawa Makoto, Kawaguchi Naoki, Kimura Takashi, Sugimoto Takamichi, Murai Hiroyuki, Yamawaki Takemori, Kaida Kenichi, Tokuyasu Daiki, Yasuda Manato, Akamine Hiroyuki, Onishi Yosuke, Ogawa Yosuke, Shirai Yuya, Edahiro Ryuya, Yamamoto Kenichi, Nagata Hideki, Ose Naoko, Takayama Jun, Suzuki Ken, Higashiue Shinichi, Kobayashi Shuzo, Yamaguchi Hiroki, Okazaki Yasushi, Matsumoto Naoyuki, Motomura Kenta, Koga Hidenobu, Matsuda Koichi, Tamiya Gen, Yamamoto Masayuki, Yamauchi Toshimasa, Kadowaki Takashi, Yamamoto Kazuhiko, Ohno Akiko, Okuno Tatsusada, Morii Eiichi, Mochizuki Hideki, Nagane Yuriko, Minami Naoya, Uzawa Akiyuki, Masuda Masayuki, Suzuki Shigeaki, Shimomura Iichiro, Shintani Yasushi, Utsugisawa Kimiaki, Takahashi Masanori P, Okada Yukinori
Abstract excerpt
Myasthenia gravis (MG) is an autoimmune disorder characterized by impaired neuromuscular transmission and motor symptoms. Its genetic background remains unclear, particularly beyond specific subtypes reported in European populations. Here, we perform a genome-wide association study (GWAS) of 1,434 MG cases covering all disease subtypes and 42,913 controls of Japanese, which newly identify the TERT locus (odds...
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