Article
Association of the DNMT3B -579G>T polymorphism with risk of thymomas in patients with myasthenia gravis.
PloS one - 1 Jan 2013
Coppedè Fabio, Ricciardi Roberta, Denaro Maria, De Rosa Anna, Provenzano Carlo, Bartoccioni Emanuela, Baggiani Angelo, Lucchi Marco, Mussi Alfredo, Migliore Lucia
Abstract excerpt
Increasing evidence suggests a contribution of epigenetic processes in promoting cancer and autoimmunity. Myasthenia gravis (MG) is an autoimmune disease mediated, in approximately 80% of the patients, by antibodies against the nicotinic acetylcholine receptor (AChR+). Moreover, epithelial tumours (thymomas) are present in about 10-20% of the patients, and there is indication that changes in DNA methylation might...
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