Article
RNA-seq-based mapping and candidate identification of mutations from forward genetic screens.
Genome research - 1 Apr 2013
Miller Adam C, Obholzer Nikolaus D, Shah Arish N, Megason Sean G, Moens Cecilia B
Abstract excerpt
Forward genetic screens have elucidated molecular pathways required for innumerable aspects of life; however, identifying the causal mutations from such screens has long been the bottleneck in the process, particularly in vertebrates. We have developed an RNA-seq-based approach that identifies both the region of the genome linked to a mutation and candidate lesions that may be causal for the phenotype of...
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