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Article

Revisiting Activation of and Mechanism of Resistance to Compound IQG-607 in Mycobacterium tuberculosis.

Antimicrobial agents and chemotherapy - 1 Feb 2018

Abbadi Bruno L, Villela Anne D, Rodrigues-Junior Valnês S, Subtil Fernanda T, Dalberto Pedro F, Pinheiro Ana P S, Santos Diógenes S, Machado Pablo, Basso Luiz A, Bizarro Cristiano V

Abstract excerpt

IQG-607 is a metal complex previously reported as a promising anti-tuberculosis (TB) drug against isoniazid (INH)-resistant strains of Mycobacterium tuberculosis Unexpectedly, we found that INH-resistant clinical isolates were resistant to IQG-607. Spontaneous mutants resistant to IQG-607 were subjected to whole-genome sequencing, and all sequenced colonies carried alterations in the katG gene. The katG(S315T)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29158273
DOI: 10.1128/AAC.02222-17
PMCID: PMC5786794

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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