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The isoniazid analog IQG-607 is not a direct substrate for the <i>Mycobacterium tuberculosis</i> catalase-peroxidase KatG

2024-09-06

Abstract excerpt

Tuberculosis (TB) is an infectious disease caused mainly by Mycobacterium tuberculosis (Mtb) and is responsible for millions of deaths. New Mtb strains resistant to TB drugs are emerging and spreading. The first-line TB drug, isoniazid (INH), must be activated inside mycobacterial cells by the catalase-peroxidase enzyme KatG to exert its antimicrobial activity, and mutations on the katG gene are a significant ca...

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Literature Corpus work
716b7159-9082-5936-9eac-cc7a67abfe55
DOI
10.1101/2024.09.05.611129
Open publication

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