Article
Novel katG mutations causing isoniazid resistance in clinical M. tuberculosis isolates.
Emerging microbes & infections - 1 Jul 2015
Torres Jessica N, Paul Lynthia V, Rodwell Timothy C, Victor Thomas C, Amallraja Anu M, Elghraoui Afif, Goodmanson Amy P, Ramirez-Busby Sarah M, Chawla Ashu, Zadorozhny Victoria, Streicher Elizabeth M, Sirgel Frederick A, Catanzaro Donald, Rodrigues Camilla, Gler Maria Tarcela, Crudu Valeru, Catanzaro Antonino, Valafar Faramarz
Abstract excerpt
We report the discovery and confirmation of 23 novel mutations with previously undocumented role in isoniazid (INH) drug resistance, in catalase-peroxidase (katG) gene of Mycobacterium tuberculosis (Mtb) isolates. With these mutations, a synonymous mutation in fabG1 (g609a), and two canonical mutations, we were able to explain 98% of the phenotypic resistance observed in 366 clinical Mtb isolates collected from...
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