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Article

Modeling the structural origins of drug resistance to isoniazid via key mutations in Mycobacterium tuberculosis catalase-peroxidase, KatG.

Tuberculosis (Edinburgh, Scotland) - 1 Jan 2018

Marney Matthew W, Metzger Robert P, Hecht David, Valafar Faramarz

Abstract excerpt

WHO reported 10.4 million new tuberculosis (TB) cases and 1.8 million deaths in 2015, making M. tuberculosis the most successful human pathogen with highest mortality among infectious diseases [1,2]. Drug-resistant TB is a major threat to global TB control [2,3]. Recently Torres et al. [4] identified 14 novel substitutions in M. tuberculosis-KatG (the enzyme associated with resistance to isoniazid-an important...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29523317
DOI: 10.1016/j.tube.2017.11.007
PMCID: PMC7330162

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