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Article

Epistasis, physical capacity-related genes and exceptional longevity: FNDC5 gene interactions with candidate genes FOXOA3 and APOE.

BMC genomics - 14 Nov 2017

Fuku Noriyuki, Díaz-Peña Roberto, Arai Yasumichi, Abe Yukiko, Zempo Hirofumi, Naito Hisashi, Murakami Haruka, Miyachi Motohiko, Spuch Carlos, Serra-Rexach José A, Emanuele Enzo, Hirose Nobuyoshi, Lucia Alejandro

Abstract excerpt

BACKGROUND: Forkhead box O3A (FOXOA3) and apolipoprotein E (APOE) are arguably the strongest gene candidates to influence human exceptional longevity (EL, i.e., being a centenarian), but inconsistency exists among cohorts. Epistasis, defined as the effect of one locus being dependent on the presence of 'modifier genes', may contribute to explain the missing heritability of complex phenotypes such as EL. We...

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Source

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Identifiers

PMID: 29143599
DOI: 10.1186/s12864-017-4194-4
PMCID: PMC5688477

Genes

APOE
FNDC5

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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