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Unraveling 'F' factor: towards a genetic-clinical framework for the musculoskeletal-heart crosstalk in metabolic aging.

Cardiovascular diabetology - 1 Jun 2026

Zhou Yunqiao, Huang Jian, Chen Xinyi, Xu Leqin, Zhang Fan, Bai Chunxiao, Yang Jiju, Fan Fangyang, Wang Yuquan, Fang Bixuan, Wang Tian, Li Junhao, Mu Xiaohong, Li Jinyu

Abstract excerpt

BACKGROUND: The rising co-occurrence of cardiometabolic diseases and musculoskeletal degeneration poses a critical challenge to healthy aging, yet the shared biological mechanisms underlying this multimorbidity remain poorly defined. This study aimed to establish an integrative clinical-genetic framework to elucidate the common frailty factor, the 'F' factor, that captures the systemic vulnerability linking...

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Age Factors
Aging
Cardiometabolic Risk Factors
Frailty
Longitudinal Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Machine Learning

Musculoskeletal Diseases

Risk Assessment

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Open in PubMed Open full text

Identifiers

PMID: 42226250
DOI: 10.1186/s12933-026-03220-1
PMCID: PMC13440131

Genes

APOE
SLC22A3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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