Article
Genetic factors and epigenetic mechanisms of longevity: current perspectives.
Epigenomics - 1 Jan 2015
Lazarus Jessica, Mather Karen A, Thalamuthu Anbupalam, Kwok John B J
Abstract excerpt
The exceptional longevity phenotype, defined as living beyond the age of 95, results from complex interactions between environmental and genetic factors. Epigenetic mechanisms, such as DNA methylation and histone modifications, mediate the interaction of these factors. This review will provide an overview of animal model studies used to examine age-related epigenetic modifications. Key human studies will be used...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.