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Article

Parkinson disease polygenic risk score is associated with Parkinson disease status and age at onset but not with alpha-synuclein cerebrospinal fluid levels.

BMC neurology - 15 Nov 2017

Ibanez Laura, Dube Umber, Saef Benjamin, Budde John, Black Kathleen, Medvedeva Alexandra, Del-Aguila Jorge L, Davis Albert A, Perlmutter Joel S, Harari Oscar, Benitez Bruno A, Cruchaga Carlos

Abstract excerpt

BACKGROUND: The genetic architecture of Parkinson's Disease (PD) is complex and not completely understood. Multiple genetic studies to date have identified multiple causal genes and risk loci. Nevertheless, most of the expected genetic heritability remains unexplained. Polygenic risk scores (PRS) may provide greater statistical power and inform about the genetic architecture of multiple phenotypes. The aim of...

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Identifiers

PMID: 29141588
DOI: 10.1186/s12883-017-0978-z
PMCID: PMC5688622

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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