Progression to Parkinson's dementia is not modulated by genetic risk variants for Alzheimer's or Parkinson's disease.

doi:10.1177/1877718X251356512

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Progression to Parkinson's dementia is not modulated by genetic risk variants for Alzheimer's or Parkinson's disease.

Journal of Parkinson's disease - 1 Nov 2025

Parveen Kayenat, Ross J Alexander, van der Wurp Hendrik, Balzer-Geldsetzer Monika, Berg Daniela, Deuschl Günther, Gasser Thomas, Hilker-Roggendorf Rüdiger, Kalbe Elke, Liepelt-Scarfone Inga, Mollenhauer Brit, Riedel Oliver, Röske Sandra, Schulz Jörg B, Spottke Annika, Storch Alexander, Trenkwalder Claudia, Kassubek Jan, Witt Karsten, Dodel Richard, Wüllner Ullrich, Ramirez Alfredo, Dalmasso Maria Carolina

Abstract excerpt

Parkinson's disease (PD) is marked by motor symptoms and often accompanied by mild cognitive impairment (PD-MCI), affecting up to 50% of patients and preceding PD dementia (PDD). Genetic factors may influence this progression, yet the underlying mechanisms remain unclear. This study investigated genetic factors influencing the progression from PD-MCI to PDD using polygenic risk scores (PRS). A genome-wide...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Alzheimer Disease

Share to Cognitive Dysfunction

Share to Dementia

Share to Disease Progression

Share to Genome-Wide Association Study

Share to Multifactorial Inheritance

Share to Parkinson Disease

Source

Open in PubMed Open full text

Identifiers

PMID: 40739885
DOI: 10.1177/1877718X251356512
PMCID: PMC13347514

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Progression to Parkinson's dementia is not modulated by genetic risk variants for Alzheimer's or Parkinson's disease.PMID 40739885Read ↗

Association of Polygenic Risk Score With Cognitive Decline and Motor Progression in Parkinson Disease.Semantic proximity Read ↗

Polygenic Risk Scores Contribute to Personalized Medicine of Parkinson’s DiseaseSemantic proximity Read ↗

Genetic risk of Parkinson's disease in the general population.Semantic proximity Read ↗

Genetic risk factors for cognitive decline in Parkinson's disease: a review of the literature.Semantic proximity Read ↗

Genetic risk factors in Parkinson's disease.Semantic proximity Read ↗

Clinical and genetic predictors of dementia in Parkinson’s diseaseSemantic proximity Read ↗

Parkinson disease polygenic risk score is associated with Parkinson disease status and age at onset but not with alpha-synuclein cerebrospinal fluid levels.Semantic proximity Read ↗

Polygenic risk score-based prediction for Parkinson’s diseaseSemantic proximity Read ↗

Genome-wide survival study identifies a novel synaptic locus and polygenic score for cognitive progression in Parkinson's disease.Semantic proximity Read ↗

Predicting risk of Alzheimer’s disease using polygenic risk scores developed for Parkinson’s diseaseSemantic proximity Read ↗

Association of Family History and Polygenic Risk Score With Longitudinal Prognosis in Parkinson DiseaseSemantic proximity Read ↗

Validity and Prognostic Value of a Polygenic Risk Score for Parkinson's Disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.