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Article

Validity and Prognostic Value of a Polygenic Risk Score for Parkinson's Disease.

Genes - 23 Nov 2021

Koch Sebastian, Laabs Björn-Hergen, Kasten Meike, Vollstedt Eva-Juliane, Becktepe Jos, Brüggemann Norbert, Franke Andre, Krämer Ulrike M, Kuhlenbäumer Gregor, Lieb Wolfgang, Mollenhauer Brit, Neis Miriam, Trenkwalder Claudia, Schäffer Eva, Usnich Tatiana, Wittig Michael, Klein Christine, König Inke R, Lohmann Katja, Krawczak Michael, Caliebe Amke

Abstract excerpt

Idiopathic Parkinson's disease (PD) is a complex multifactorial disorder caused by the interplay of both genetic and non-genetic risk factors. Polygenic risk scores (PRSs) are one way to aggregate the effects of a large number of genetic variants upon the risk for a disease like PD in a single quantity. However, reassessment of the performance of a given PRS in independent data sets is a precondition for...

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Identifiers

PMID: 34946808
DOI: 10.3390/genes12121859
PMCID: PMC8700849

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