Article

Parkinson disease age of onset GWAS: defining heritability, genetic loci and a-synuclein mechanisms

2018-10-11

Abstract excerpt

Increasing evidence supports an extensive and complex genetic contribution to Parkinson’s disease (PD). Previous genome-wide association studies (GWAS) have shed light on the genetic basis of risk for this disease. However, the genetic determinants of PD age of onset are largely unknown. Here we performed an age of onset GWAS based on 28,568 PD cases. We estimated that the heritability of PD age of onset due to co...

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Literature Corpus work: 374b11d7-1071-5bfd-a107-e9c2b31d65c5
DOI: 10.1101/424010

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