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Article

Polygenic risk of Parkinson disease is correlated with disease age at onset.

Annals of neurology - 1 Apr 2015

Escott-Price Valentina, Nalls Mike A, Morris Huw R, Lubbe Steven, Brice Alexis, Gasser Thomas, Heutink Peter, Wood Nicholas W, Hardy John, Singleton Andrew B, Williams Nigel M

Abstract excerpt

OBJECTIVE: We have investigated the polygenic architecture of Parkinson disease (PD) and have also explored the potential relationship between an individual's polygenic risk score and their disease age at onset. METHODS: This study used genotypic data from 4,294 cases and 10,340 controls obtained from the meta-analysis of PD genome-wide association studies. Polygenic score analysis was performed as previously...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25773351
DOI: 10.1002/ana.24335
PMCID: PMC4737223

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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