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Article

Reduced Expression of Glutathione S-Transferase α 4 Promotes Vascular Neointimal Hyperplasia in CKD.

Journal of the American Society of Nephrology : JASN - 1 Feb 2018

Luo Jinlong, Chen Guang, Liang Ming, Xie Aini, Li Qingtian, Guo Qunying, Sharma Rajendra, Cheng Jizhong

Abstract excerpt

Neointima formation is the leading cause of arteriovenous fistula (AVF) failure. We have shown that CKD accelerates this process by transforming the vascular smooth muscle cells (SMCs) lining the AVF from a contractile to the synthetic phenotype. However, the underlying mechanisms affecting this transformation are not clear. Previous studies have shown that the α-class glutathione transferase isozymes have an...

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Source

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Identifiers

PMID: 29127112
DOI: 10.1681/ASN.2017030290
PMCID: PMC5791085

Genes

GSTA4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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