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Article

The Autotaxin-LPA Axis Emerges as a Novel Regulator of Smooth Muscle Cell Phenotypic Modulation during Intimal Hyperplasia.

International journal of molecular sciences - 2 Feb 2023

Subedi Utsab, Manikandan Shrivats, Bhattarai Susmita, Sharma Papori, Sharma Sudha, Sun Hong, Miriyala Sumitra, Panchatcharam Manikandan

Abstract excerpt

Neointimal hyperplasia is characterized by a loss of the contractile phenotype of vascular smooth muscle cells (VSMCs). Our group has recently shown that VSMC proliferation and migration are mediated by lysophosphatidic acid (LPA) during restenosis, but the role of autotaxin (ATX; lysophospholipase D), which produces LPA, remains unclear. Endothelial denudation of the mouse carotid artery was performed to induce...

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Identifiers

PMID: 36769255
DOI: 10.3390/ijms24032913
PMCID: PMC9917461

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